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ViscoTec supplies the right dosing technology for your requirements in the field of medical and industrial biotechnology applications in particular. The continuous, low shear dosing of inocula, substrates and products ensures that the biotechnological process is not significantly affected. The dosing technology used is suitable for CIP/SIP or for autoclave sterilisation. Systems are planned and manufactured in accordance with well-known standards (QHD, 3A SSI, GMP, DIN 11864). Inspection certificate 3.1 in accordance with EN 10204:2204 for parts which come into contact with the product forms part of the system documentation.

Filling enzyme suspensions

ViscoTec - Biotechnology - multi-dosing-system for filling enzyme suspensions

Filling enzyme suspensions

A multi-dosing system is needed to automatically fill enzyme suspensions into glass vials. The enzymes are extremely sensitive to shearing.
A ViscoTec pharmaceutical dispenser is attached above every filling station. Each dispenser can be calibrated in terms of dosing quantity independently, with a correspondingly high level of dosing precision (> 99%). The expensive product is then dosed highly precisely with no rheological stress. Once the product has been delivered, the pharmaceutical dispensers are dismantled, cleaned and sterilised without the need for tools.

Dosing of inocula in a substrate flow

ViscoTec dosing inocula substrate

Dosing of inocula in a substrate flow

When filling a fermenter, thick paste-like inocula with a high cell count are added to the inflowing substrate in a defined dosage. The substrate’s volume flow is measured by the fermenter control and the power of the dosing pump is adapted to it using a simple analogue signal. The special rotor-stator geometry provides the inocula cells with optimum protection against an excessive shearing load during dosing. The fermenter’s PLC acts as a higher-level controller, managing the ViscoTec dosing control via Profinet in the fermenter’s various operating modes (filling, cleaning, sterilisation, etc.).

Dosing of a culture medium into Petri dishes

ViscoTec culture medium petri dishes micro-organism

Dosing of a culture medium into Petri dishes

A complex culture medium for cultivating micro-organisms is dosed into Petri dishes. The dosing temperature of the medium is around 50 °C. The same medium is to be dosed into the Petri dishes in different quantities.
The dosing procedure is performed fully automatically in a sterile area of the filling machine. The dosing quantity can be adapted via the software – there is no need to mechanically modify the dosing system, which would require the sterile room to be opened. The dosing pump is dismantled, cleaned and sterilised in an autoclave at intervals.

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